Preparation of 5-Substituted 1H-Tetrazoles from Nitriles in Water†

作者: Zachary P. Demko , K. Barry Sharpless

DOI: 10.1021/JO010635W

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摘要: … ,c tetrazole formation proceeds with excellent yields and scope in refluxing water. Thanks to the low pK a of 1H-tetrazoles (… acidification is usually sufficient to provide the pure tetrazoles. …

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