Antioxidant Vitamin Intake and Coronary Mortality in a Longitudinal Population Study

摘要: Oxidation of lipoproteins is hypothesized to promote atherosclerosis and, thus, a high intake antioxidant nutrients may protect against coronary heart disease. The relation between the intakes dietary carotene, vitamin C, and E subsequent mortality was studied in cohort 5,133 Finnish men women aged 30-69 years initially free from Food consumption estimated by history method covering total habitual diet during previous year. Altogether, 244 new fatal disease cases occurred mean follow-up 14 beginning 1966-1972. An inverse association observed both with relative risks 0.68 (p for trend = 0.01) 0.35 < 0.01), respectively, highest lowest tertiles intake. Similar associations were C carotenoids among important food sources these micronutrients, i.e., vegetables fruits, women. not attributable confounding major nondietary risk factors disease, age, smoking, serum cholesterol, hypertension, or weight. results support hypothesis that vitamins but it cannot be excluded foods rich micronutrients also contain other constituents provide protection.