A comparative study of stabilising effect and antioxidant activity of different antioxidants on levodopa-loaded liposomes.
作者： Elena García Esteban , María José Cózar-Bernal , Antonio M. Rabasco Álvarez , María Luisa González-Rodríguez
DOI: 10.1080/02652048.2018.1487473
关键词:
摘要: The aim of this study was to evaluate the stability levodopa liposomes co-loaded with three different antioxidants (curcumin, ascorbic acid, and superoxide dismutase (SOD)). For purpose, multilamellar were prepared. Curcumin added into lipid bilayer while acid SOD placed aqueous phase. influence preparation technique surface charge also investigated. Vesicles characterised free radical scavenging potential determined. From study, showed better stabilising effect. These exhibited activity where played a key role. techniques charge, we concluded that cationic made by Thin Layer Evaporation following extrusion offered best physicochemical properties. A dual mechanism these implies chemical stabilisation (dose reduction) antioxidant effect, preventive effect on Parkinson's disease.
sci-hub.se 参考文章(55)
Howard S. Mason, Charles I. Wright, THE CHEMISTRY OF MELANIN: V. OXIDATION OF DIHYDROXYPHENYLALANINE BY TYROSINASE Journal of Biological Chemistry. ,vol. 180, pp. 235- 247 ,(1949) , 10.1016/S0021-9258(18)56739-9
Kuo-Hsuan Chang, Chiung-Mei Chen, The Role of Oxidative Stress in Parkinson’s Disease Journal of Parkinson's disease. ,vol. 3, pp. 461- 491 ,(2013) , 10.3233/JPD-130230
AKASH YADAV, D K Jain, PREPARATION AND CHARACTERIZATION OF MICROPARTICULATE SYSTEM OF PROPRANOLOL HYDROCHLORIDE Journal of Drug Delivery and Therapeutics. ,vol. 1, ,(2011) , 10.22270/JDDT.V1I2.42
D Allan Butterfield, Miranda L Bader Lange, Rukhsana Sultana, None, Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease. Biochimica et Biophysica Acta. ,vol. 1801, pp. 924- 929 ,(2010) , 10.1016/J.BBALIP.2010.02.005
Ajay Goel, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal, Curcumin as “Curecumin”: From kitchen to clinic Biochemical Pharmacology. ,vol. 75, pp. 787- 809 ,(2008) , 10.1016/J.BCP.2007.08.016
Carlos Spuch, Carmen Navarro, Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease). Journal of drug delivery. ,vol. 2011, pp. 469679- 469679 ,(2011) , 10.1155/2011/469679
F. Maestrelli, M.L. González-Rodríguez, A.M. Rabasco, C. Ghelardini, P. Mura, New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics. International Journal of Pharmaceutics. ,vol. 395, pp. 222- 231 ,(2010) , 10.1016/J.IJPHARM.2010.05.046
Sawsan A Zaitone, Lamiaa N Hammad, Noha E Farag, None, Antioxidant potential of melatonin enhances the response to L-dopa in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-parkinsonian mice Pharmacological Reports. ,vol. 65, pp. 1213- 1226 ,(2013) , 10.1016/S1734-1140(13)71479-8
A Manosroi, K Podjanasoonthon, K Foe, J Manosroi, Development of novel topical tranexamic acid liposome formulations International Journal of Pharmaceutics. ,vol. 235, pp. 61- 70 ,(2002) , 10.1016/S0378-5173(01)00980-2
Navaneethaiyer Umasuthan, Kasthuri Saranya Revathy, S.D.N.K. Bathige, Bong-Soo Lim, Myoung-Ae Park, Ilson Whang, Jehee Lee, A manganese superoxide dismutase with potent antioxidant activity identified from Oplegnathus fasciatus: genomic structure and transcriptional characterization. Fish & Shellfish Immunology. ,vol. 34, pp. 23- 37 ,(2013) , 10.1016/J.FSI.2012.09.011