Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease.

摘要: Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical clinical studies using extracts derived from molluscs, as well traditional molluscan medicines, used in treatment respiratory diseases. We reviewed 97 biomedical articles demonstrating anti-inflammatory, antimicrobial, anticancer, immunomodulatory properties >320 extracts/compounds with direct relevance to disease, addition others promising bioactivities yet be tested context. Of pertinent interest are biofilm inhibition/disruption antiviral activity, synergism approved antimicrobial chemotherapeutic agents. At least 100 incorporating over 300 different mollusc species, have been treat respiratory-related illness cultures worldwide thousands years. These medicines provide useful clues bioactive components that likely underpin their continued use. There particular incentive investigations into anti-inflammatory compounds, given extensive application symptoms inflammation, shells, which principal product these preparations. Overall, target toward specific disease-related hypotheses, purify elucidate chemical structures, develop evidence base integration quality-controlled medicines.