Decreased Egr-1 expression in human, mouse and rat mammary cells and tissues correlates with tumor formation
作者： Ruo-Pan Huang , Yan Fan , Ian De Belle , Christina Niemeyer , Marco M. Gottardis
DOI: 10.1002/(SICI)1097-0215(19970703)72:1<102::AID-IJC15>3.0.CO;2-L
关键词:
摘要: We have examined several types of tumor cell lines and shown that they invariably expressed little or no Egr-1, in contrast to their normal counterparts. previously the expression exogenous Egr-1 human breast other cells markedly reduces transformed growth tumorigenicity. therefore hypothesized loss plays a role transformation. All mouse cancer tumors had reduced compared with Reduced was also observed 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, this level increased levels regressed after tamoxifen treatment. concluded, therefore, may play deregulation tumorigenic process acts as suppressor gene.
sci-hub.se 参考文章(19)
Ruo-Pan Huang, E. D. Adamson, A biological role for Egr-1 in cell survival following ultra-violet irradiation. Oncogene. ,vol. 10, pp. 467- 475 ,(1995)
R. Sager, S. Sheng, P. Pemberton, M. J. C. Hendrix, Maspin: A Tumor Suppressing Serpin Attempts to Understand Metastasis Formation I. ,vol. 213, pp. 51- 64 ,(1996) , 10.1007/978-3-642-61107-0_4
Lawrence W. Anderson, Keith G. Danielson, Howard L. Hosick, New cell line. Epithelial cell line and subline established from premalignant mouse mammary tissue. In Vitro Cellular & Developmental Biology – Plant. ,vol. 15, pp. 841- 843 ,(1979) , 10.1007/BF02618037
Ruth Sager, Anthony Anisowicz, Mark Neveu, Peng Liang, Georgia Sotiropoulou, Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene. The FASEB Journal. ,vol. 7, pp. 964- 970 ,(1993) , 10.1096/FASEBJ.7.10.8344495
Frank J. Rauscher III, The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. The FASEB Journal. ,vol. 7, pp. 896- 903 ,(1993) , 10.1096/FASEBJ.7.10.8393820
Hung Q. Nguyen, Barbara Hoffman-Liebermann, Dan A. Liebermann, The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage Cell. ,vol. 72, pp. 197- 209 ,(1993) , 10.1016/0092-8674(93)90660-I
B. Christy, D. Nathans, DNA binding site of the growth factor-inducible protein Zif268. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 8737- 8741 ,(1989) , 10.1073/PNAS.86.22.8737
Ruo-Pan Huang, Lan Ngo, Daryl Okamura, Mark Tucker, Eileen D. Adamson, V‐sis induces Egr‐1 expression by a pathway mediated by c‐Ha‐ras Journal of Cellular Biochemistry. ,vol. 56, pp. 469- 479 ,(1994) , 10.1002/JCB.240560407
C. Liu, E. Adamson, D. Mercola, Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11831- 11836 ,(1996) , 10.1073/PNAS.93.21.11831
S. W. Lee, C. Tomasetto, R. Sager, Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 2825- 2829 ,(1991) , 10.1073/PNAS.88.7.2825