Turning the tables on surgical oncology: The • Pancho trial unplugged
作者： S. Kappel , C. Bichler , B. Wolf , S. Gacic , S. F. Schoppmann
DOI: 10.1007/S10353-008-0438-5
关键词:
摘要: BACKGROUND: In esophageal cancer patients neoadjuvant therapy failed to demonstrate a clear benefit in overall survival. A significant advantage can be seen with complete pathological response. METHODS: This review summarizes the results of retrospective clinical studies suggesting p53 as predictive marker for chemotherapy To advance these findings level evidence I • Pancho trial was initiated. RESULTS: The represents first prospective randomized testing interaction between and response chemotherapy. special design (interaction design), sample size considerations, study endpoints 12 months accrual this nationwide are reported. CONCLUSIONS: evaluates time whether genotype is qualified select who will respond certain guide therapy.
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