Response prediction in cancer treatment (p53 adapted cancer therapy)
作者： Daniela Kandioler
DOI:
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摘要: The invention discloses a method for diagnosing tumour patient (i) whether the should be treated with therapy inducing p53 dependent apoptosis or interfering cell cycle and/or (ii) must not which is characterised by following steps: - determining genetic status of patient's respect to in sample body fluid tissue containing cells cell-free DNA whole gene present native form has one more mutations; as (i) who if (ii) mutations form.
lens.org 参考文章(11)
S. Kappel, C. Bichler, B. Wolf, S. Gacic, S. F. Schoppmann, Y. Devyatko, G. Prager, A. Ba-SSalamah, F. Wrba, U. Pluschnig, I. Kührer, M. Mittlböck, M. Hejna, J. Zacherl, D. Kandioler, Turning the tables on surgical oncology: The • Pancho trial unplugged European Surgery-acta Chirurgica Austriaca. ,vol. 40, pp. 277- 283 ,(2008) , 10.1007/S10353-008-0438-5
Steve Rozen, Helen Skaletsky, Primer3 on the WWW for general users and for biologist programmers. Methods of Molecular Biology. ,vol. 132, pp. 365- 386 ,(2000) , 10.1385/1-59259-192-2:365
John K. Stevens, Eleftherios Diamandis, James M. Dunn, Method, reagents and kit for diagnosis and targeted screening for p53 mutations ,(1995)
Hajime Matsuzaki, Eric A. Murphy, Methods and compositions for multiplex amplification of nucleic acids ,(2003)
Audrey Petitjean, Ewy Mathe, Shunsuke Kato, Chikashi Ishioka, Sean V. Tavtigian, Pierre Hainaut, Magali Olivier, Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Human Mutation. ,vol. 28, pp. 622- 629 ,(2007) , 10.1002/HUMU.20495
Daniela Kandioler, Georgios Stamatis, Wilfried Eberhardt, Sonja Kappel, Sabine Zöchbauer-Müller, Irene Kührer, Martina Mittlböck, Ronald Zwrtek, Clemens Aigner, Christoph Bichler, Victoria Tichy, Marcus Hudec, Thomas Bachleitner, Adelheid End, Michael Rolf Müller, Erich Roth, Walter Klepetko, Growing clinical evidence for the interaction of the p53 genotype and response to induction chemotherapy in advanced non-small cell lung cancer. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 135, pp. 1036- 1041 ,(2008) , 10.1016/J.JTCVS.2007.10.072
Sergey V Tokalov, Nasreddin D Abolmaali, Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment BMC Cancer. ,vol. 10, pp. 57- 57 ,(2010) , 10.1186/1471-2407-10-57
Martina Mittlböck, Daniela Kandioler-Eckersberger, Michael Gnant, Günter Steger, Margarethe Rudas, Elisabeth Janschek, Sonja Kappel, Catharina Wenzel, Raimund Jakesz, Carmen Ludwig, Hermine Schlagbauer-Wadl, TP53 Mutation and p53 Overexpression for Prediction of Response to Neoadjuvant Treatment in Breast Cancer Patients Clinical Cancer Research. ,vol. 6, pp. 50- 56 ,(2000)
D. Kandioler, M. Hejna, R. Zwrtek, S. Kappel, C. Bichler, F. Wrba, A. Ba-Ssalamah, C. Zielinski, R. Jakesz, J. Zacherl, , p53 adapted neoadjuvant therapy for esophageal cancer: Pilot study Journal of Clinical Oncology. ,vol. 25, pp. 4535- 4535 ,(2007) , 10.1200/JCO.2007.25.18_SUPPL.4535
Doerken Bernd, Hillebrand Timo, Bendzko Peter, Daniel Peter, Method for detecting the effect of different chemotherapeutic agents and/or radiation therapy in malignant diseases and method for selecting more effective therapeutic agents for the therapy thereof ,(2000)