Peripheral T-cell lymphomas of the intestine.

摘要: Twenty-seven cases of primary peripheral T-cell lymphomas the intestine (PTLI) were investigated. Seven patients had histories malabsorption. The most frequent symptoms at presentation weight loss, abdominal pain, and acute abdomen. jejunum was common site lymphoma multifocal disease found in 72% cases. Twenty-two (92%) presented with localized confined to lymph nodes, only two generalized disease. According pattern infiltration morphology uninvolved small intestinal mucosa, 21 separated histologically into three categories; 1) enteropathy-associated (EATCL, n = 9) showing predominant intramucosal spread villous atrophy mucosa high density intraepithelial lymphocytes (IEL), 2) EATCL-like without enteropathy (EATCL-LLWE, 5) but an similar EATCL, 3) features EATCL (Non-EATCL, 7). Distinctive incidence malabsorption states, all cases, frequency recurrences. On frozen sections four eight PTLI showed phenotype CD3+ CD4- CD8- HML-1+, which is also expressed on a subset normal IEL. morphologic immunomorphologic findings suggest that majority derived from mucosal T lymphocytes. This derivation may be responsible for certain biologic features, such as preferential relapse sites.