Validation of the scanning γ-ray telescope for in vivo dosimetry and boron measurements during BNCT

摘要: γ-ray telescope scans of a box phantom with inhomogeneous boron concentrations have proven the feasibility in vivo measurements different distributions head patient during neutron capture therapy (BNCT). Small structures enhanced concentration can be reconstructed phantom, even if brain compartment is surrounded by skin layer ten times higher concentration. The motor-controlled scan head/phantom, detecting and hydrogen prompt γ-rays emitted at reactions two-dimensional spatial resolution 14 mm full width half maximum. For reconstruction from measured detection rates, mathematical algorithm derived discussed. Proper requires position-dependent combined treatment planning programme calculations thermal distribution. In which skull (bulk) were represented using homogeneous distribution 5.2 ± 0.5 ppm 10B, concentration, bulk was to 4.7 0.3 10B. Telescope along perpendicular beam axis showed influence inhomogeneities high such as simulated blood vessel, respectively low white matter. profiles rates indicate how future interpreted. clinical trials, then used investigate averaged local (e.g. tumour tissue) order relate dose effects BNCT. Simultaneously, it serve quality control dosimetry irradiation.