Cardiovascular Pharmacology of Propranolol in Man

摘要: The success of propranolol in treating the symptoms angina pectoris has raised questions about effects beta-adrenergic blockade on hemodynamic functions, myocardial mechanics, energetics, and metabolic functions. Five milligrams was given intravenously to 27 human subjects, 18 with nine without angiographically proven coronary atherosclerosis. drug produced a decrease externally measured indices mechanical effort consequently fall oxygen demands. changes resultant increases consumption flow during supine leg exercise were also attenuated. Propranolol different arteriovenous extraction depending upon whether circulation normal or diseased. Although data suggest that vasoconstriction occurred patients atherosclerotic lesions, no significant change lactate exchange noted after administratio...