Comprehensive multiresidue method for the simultaneous determination of 74 pesticides and metabolites in traditional Chinese herbal medicines by accelerated solvent extraction with high-performance liquid chromatography/tandem mass spectrometry.

摘要: In this paper, a multiresidue method for the simultaneous target analysis of 74 pesticides and metabolites in traditional Chinese herbal medicines (TCHMs) was developed using accelerated solvent extraction (ASE) coupled with HPLC/MS/MS. Pesticide residues were extracted from different samples ASE, then purified by gel permeation chromatography graphitized carbon black/primary, secondary amine SPE. Gradient elution used conjunction positive mode electrospray ionization MS/MS to detect Cortex Cinnamomi, Flos Carthami, Folium Ginkgo, Herba Pogostemonis, Radix Ginseng, Semen Ginkgo single chromatographic run. The analytical performance demonstrated extracts spiked at three concentration levels ranging 0.005 0.125 mg/kg each pesticide metabolite. general, recoveries 70 110%, RSDs better than 15%, obtained. recovery repeatability data good accordance European Union guidelines residue analysis. LOD most targeted tested below 0.01 mg/kg.