Outpatient Treatment of 'Crack' Cocaine Smoking With Flupenthixol Decanoate

摘要: • "Crack" cocaine abuse often produces severe dependence that is refractory to available pharmacological and outpatient psychotherapeutic treatments. We conducted two preliminary investigations evaluating the efficacy of flupenthixol decanoate, a depot xanthene requiring infrequent intramuscular administration, in treatment withdrawal. Ten crack smokers with poor prognoses were administered decanoate an open-label, open-ended trial. Flupenthixol was well tolerated appeared decrease craving use markedly rapidly, producing 260% increase average time retained among these subjects. These promising but data, combined magnitude problems presented by crack, warrant rapid, expanded double-blind assessment cocaine-abuse treatment.