Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2
作者： Sonika Patial Sonika Patial , VK Chaturvedi , A Rai , M Saini , Rajesh Chandra Rajesh Chandra
DOI: 10.1016/J.VACCINE.2007.02.051
关键词:
摘要: A bicistronic DNA vaccine against rabies and parvovirus infection of dogs was developed by subcloning glycoprotein canine (CPV) VP2 genes into a vector. After characterizing the expression both proteins in vitro, injected mice induced immune response compared with monocistronic vaccines. There no significant difference ELISA virus neutralizing (VN) antibody responses CPV immunized either or vaccine. Further, there significantly similar protection on challenge. Similarly, vaccines comparable VN antibodies CPV. This study indicated that can be used to induce
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