The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases.

摘要: The implication of the renin-angiotensin system (RAS) in regulation cardiovascular has been well known for many years. Accordingly, pharmaceutical inhibitors have developed to treat several pathologies, like hypertension and heart failure, angiotensin converting enzyme (ACE) became one major target treatment these diseases. In last decade however, it become apparent that classical view RAS was not quite accurate. For instance, ACE shown work only by generating angiotensin-II but also interacting with receptors outside system. Moreover, local are present different tissues, such as heart, brain, kidney vasculature. However, past, impossible determine role systems they were pharmacologically indistinguishable from systemic RAS. Hence, recent years, development transgenic animals allowed us implicated roles had originally attributed exclusively action almost 30% medicated hypertensive patients harboring an uncontrolled blood pressure, a need new drugs targets appears necessary. With century came discovery homolog ACE, called ACE2, early studies suggest may play pivotal controlling balance between vasoconstrictor effects angiotensin- II vasodilatory properties angiotensin1-7 peptide. Like ACE2 hydrolyze peptides related identified receptor severe acute respiratory syndrome (SARS) coronavirus. Although tissue localization though be very restricted, emerged showing more widespread distribution. Therefore, whole dynamics re-evaluated light this information. review, we will compare structures, distributions its homologue context function, focusing on autocrine/paracrine cardiac brain data literature our laboratory offering perspective potential