Risk of Diabetes After Hysterectomy With or Without Oophorectomy in Postmenopausal Women.
作者： Juhua Luo , JoAnn E. Manson , Rachel Peragallo Urrutia , Michael Hendryx , Erin S. LeBlanc
DOI: 10.1093/AJE/KWX023
关键词:
摘要: The aim of this study was to determine the associations between hysterectomy, bilateral salpingo-oophorectomy (BSO), and incidence diabetes in postmenopausal women participating Women's Health Initiative (WHI), a series trials conducted United States, during period 1993-1998. A total 67,130 aged 50-79 years were followed for mean 13.4 years. Among them, 7,430 cases diagnosed. Multivariable Cox proportional hazards models used assess association hysterectomy/oophorectomy status incidence. Compared with without hysterectomy had significantly higher risk (hazard ratio = 1.13, 95% confidence interval: 1.06, 1.21). increased similar only concomitant BSO. alone, BSO not associated additional after stratification by age at hormone therapy status. In our large, prospective study, we observed that regardless oophorectomy status, among women. However, data did support hypothesis early loss ovarian estrogens is factor type 2 diabetes. modest may be due residual confounding, such as reasons hysterectomy.
oup.com
sci-hub.se 参考文章(41)
D. E. Bonds, N. Lasser, L. Qi, R. Brzyski, B. Caan, G. Heiss, M. C. Limacher, J. H. Liu, E. Mason, A. Oberman, M. J. O’Sullivan, L. S. Phillips, R. J. Prineas, L. Tinker, The effect of conjugated equine oestrogen on diabetes incidence: The Women's Health Initiative randomised trial Diabetologia. ,vol. 49, pp. 459- 468 ,(2006) , 10.1007/S00125-005-0096-0
Jennifer Hays, Julie R Hunt, F.Allan Hubbell, Garnet L Anderson, Marian Limacher, Catherine Allen, Jacques E Rossouw, The women's health initiative recruitment methods and results Annals of Epidemiology. ,vol. 13, ,(2003) , 10.1016/S1047-2797(03)00042-5
Anne Dørum, Serena Tonstad, Astrid H. Liavaag, Trond Melbye Michelsen, Bjørn Hildrum, Alv A. Dahl, Bilateral oophorectomy before 50 years of age is significantly associated with the metabolic syndrome and Framingham risk score: a controlled, population-based study (HUNT-2). Gynecologic Oncology. ,vol. 109, pp. 377- 383 ,(2008) , 10.1016/J.YGYNO.2008.02.025
Shilpi Pandey, Siladitya Bhattacharya, Impact of obesity on gynecology Women's Health. ,vol. 6, pp. 107- 117 ,(2010) , 10.2217/WHE.09.77
Catharina M. Korse, Johannes M.G. Bonfrer, Marc van Beurden, René H.M. Verheijen, Matti A. Rookus, Estradiol and testosterone levels are lower after oophorectomy than after natural menopause. Tumor Biology. ,vol. 30, pp. 37- 42 ,(2009) , 10.1159/000199449
Joanne Kotsopoulos, Amy L. Shafrir, Megan Rice, Susan E. Hankinson, A. Heather Eliassen, Shelley S. Tworoger, Steven A. Narod, The Relationship Between Bilateral Oophorectomy and Plasma Hormone Levels in Postmenopausal Women Hormones and Cancer. ,vol. 6, pp. 54- 63 ,(2015) , 10.1007/S12672-014-0209-7
Cathleen M. Rivera, Brandon R. Grossardt, Deborah J. Rhodes, Robert D. Brown, Véronique L. Roger, L. Joseph Melton, Walter A. Rocca, Increased cardiovascular mortality after early bilateral oophorectomy. Menopause. ,vol. 16, pp. 15- 23 ,(2009) , 10.1097/GME.0B013E31818888F7
Marcia L Stefanick, Barbara B Cochrane, Judith Hsia, David H Barad, James H Liu, Susan R Johnson, The Women's Health Initiative postmenopausal hormone trials: Overview and baseline characteristics of participants Annals of Epidemiology. ,vol. 13, ,(2003) , 10.1016/S1047-2797(03)00045-0
Gail A. Laughlin, Elizabeth Barrett-Connor, Donna Kritz-Silverstein, Denise von Mühlen, Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. The Journal of Clinical Endocrinology and Metabolism. ,vol. 85, pp. 645- 651 ,(2000) , 10.1210/JCEM.85.2.6405
S. KUMAGAI, A. HOLMÄNG, P. BJÖRNTORP, The effects of oestrogen and progesterone on insulin sensitivity in female rats. Acta Physiologica Scandinavica. ,vol. 149, pp. 91- 97 ,(1993) , 10.1111/J.1748-1716.1993.TB09596.X