The Relationship Between Bilateral Oophorectomy and Plasma Hormone Levels in Postmenopausal Women

摘要: Oophorectomy prior to natural menopause reduces breast cancer risk. We evaluated whether timing of oophorectomy (during premenopause vs. postmenopause) or hysterectomy was associated with hormone levels, specifically estradiol, estrone, estrone sulfate, testosterone, sex binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), and prolactin, using data from the Nurses’ Health Study. included 2,251 postmenopausal women not hormones who provided blood samples in 1989–1990 and/or 2000–2002, were controls various nested case–control studies. used multivariate linear mixed-effects models assess geometric mean levels by surgery status. Bilateral 25 % lower testosterone versus (20.8 15.5 ng/dL) (P < 0.0001) no effect = 0.80). SHBG among a premenopausal (52.2 nmol/L) those (58.1 (62.0 0.02). There significant association DHEAS, prolactin ≥ 0.23). A simple 8 0.03) 14 DHEAS 0.02) compared but other levels. Although limited small numbers, our findings suggest differential influence on The reduction suggests possible role this development.