The association of surgical versus natural menopause with future left ventricular structure and function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

摘要: Objective To evaluate the association between surgical menopause (SM) versus natural (NM) in relation to later left ventricular (LV) structure and function, while taking into account LV parameters other cardiovascular disease risk factor (CVDRF) levels that predate menopausal transition. Methods We studied 825 premenopausal women from Coronary Artery Risk Development Young Adults study 1990 1991 (baseline, mean age 32 years) who reached by 2010 2011 had echocardiograms at these two time points. Results During 20 years of follow-up, 508 NM, whereas 317 underwent SM (34% bilateral oophorectomy). At baseline, were more likely be black, younger, have greater parity, higher values systolic blood pressure, body mass index, also lower high-density lipoprotein cholesterol physical activity than NM. No significant differences structure/function found groups. In 2011, significantly mass, mass/volume ratio, E/e' impaired longitudinal circumferential strain NM women. with oophorectomy adverse measures hysterectomy ovarian conservation. Controlling for baseline echocardiographic CVDRF linear regression models eliminated Further adjustment menopause/surgery hormone therapy use did not change results. Conclusion this study, function observed among compared explained their unfavorable presurgical profiles, suggesting rather gynecologic surgery predispose elevated future risk.