Screens, iron, and leukemia.

作者: Richard M. Stone , Daniel J. DeAngelo

DOI: 10.1182/BLOOD-2009-08-234161

关键词:

摘要: In this issue of Blood , Eberhard and colleagues screen a large library off-patent agents for down-regulation the survivin promoter in HeLa cells. Their most specific “hit” was ciclopirox, formerly developed as an antifungal, which found to have preclinical antileukemic activity

参考文章(6)
C. K. Hahn, K. N. Ross, I. M. Warrington, R. Mazitschek, C. M. Kanegai, R. D. Wright, A. L. Kung, T. R. Golub, K. Stegmaier, Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 9751- 9756 ,(2008) , 10.1073/PNAS.0710413105
Kimberly Stegmaier, Steven M. Corsello, Kenneth N. Ross, Jenny S. Wong, Daniel J. DeAngelo, Todd R. Golub, Gefitinib induces myeloid differentiation of acute myeloid leukemia. Blood. ,vol. 106, pp. 2841- 2848 ,(2005) , 10.1182/BLOOD-2005-02-0488
Yanina Eberhard, Sean P. McDermott, Xiaoming Wang, Marcela Gronda, Amudha Venugopal, Tabitha E. Wood, Rose Hurren, Alessandro Datti, Robert A. Batey, Jeffrey Wrana, William E. Antholine, John E. Dick, Aaron D. Schimmer, Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. ,vol. 114, pp. 3064- 3073 ,(2009) , 10.1182/BLOOD-2009-03-209965
Steven M. Corsello, Giovanni Roti, Kenneth N. Ross, Kwan T. Chow, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Andrew L. Kung, Todd R. Golub, Kimberly Stegmaier, Identification of AML1-ETO modulators by chemical genomics. Blood. ,vol. 113, pp. 6193- 6205 ,(2009) , 10.1182/BLOOD-2008-07-166090
David G. Covell, Ruili Huang, Anders Wallqvist, Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data Molecular Cancer Therapeutics. ,vol. 6, pp. 2261- 2270 ,(2007) , 10.1158/1535-7163.MCT-06-0787
Rebecca B. Klisovic, William Blum, Xiaohui Wei, Shujun Liu, Zhongfa Liu, Zhiliang Xie, Tamara Vukosavljevic, Cheryl Kefauver, LeNguyen Huynh, Jiuxia Pang, James A. Zwiebel, Steven Devine, John C. Byrd, Michael R. Grever, Kenneth Chan, Guido Marcucci, Phase I Study of GTI-2040, an Antisense to Ribonucleotide Reductase, in Combination with High-Dose Cytarabine in Patients with Acute Myeloid Leukemia Clinical Cancer Research. ,vol. 14, pp. 3889- 3895 ,(2008) , 10.1158/1078-0432.CCR-08-0109