Healthy lifestyle and risk of breast cancer among postmenopausal women in the European Prospective Investigation into Cancer and Nutrition cohort study

摘要: Breast cancer is the most common among women and prevention strategies are needed to reduce incidence worldwide. A healthy lifestyle index score (HLIS) was generated investigate joint effect of modifiable factors on postmenopausal breast risk. The study included 242,918 from multinational European Prospective Investigation into Cancer Nutrition (EPIC) cohort, with detailed information diet assessed at baseline. HLIS constructed five (diet, physical activity, smoking, alcohol consumption anthropometry) by assigning scores 0-4 categories each component, for which higher values indicate healthier behaviours. Hazard ratios (HR) were estimated Cox proportional regression models. During 10.9 years median follow-up, 7,756 incident cases identified. There a 3% lower risk per point increase HLIS. inversely associated high when fourth versus second (reference) compared [adjusted HR=0.74; 95% confidence interval (CI): 0.66-0.83]. category hormone receptor double positive (adjusted HR=0.81, CI: 0.67-0.98) negative HR=0.60, 0.40-0.90). Findings suggest having an combined behaviours reduces developing women. Programmes engage in long term health should be supported. What's new? How much does behavior really affect risk? These authors set out measure just that. First, they created Healthy Lifestyle Index, quantified behaviors, such as smoking activity. Then, using data (EPIC), assigned participant between 0 4 behaviors. It turned that added person's Index score, fell 3%, suggesting public programs help maintain these behaviors could worthwhile prevention.