A RAD52 genetic variant located in a miRNA binding site is associated with glioma risk in Han Chinese.

摘要: As a crucial homologous recombination repair gene, RAD52 participates in maintenance of genomic stability and prevention tumorigenesis. Although several cancer susceptibility single nucleotide polymorphisms (SNPs) have been identified previously, little was known on how the SNPs are involved glioma development Han Chinese. Therefore, we examined association between five (rs1051669, rs10774474, rs11571378, rs7963551 rs6489769) risk using case–control design. Odds ratios (ORs) 95 % confidence intervals (CIs) were estimated by logistic regression. We found that only SNP significantly associated with risk, odds having AC or CC genotype patients 0.49 (95 CI 0.37–0.65, P = 9.2 × 10−6) 0.39 0.18–0.81, 0.012) compared AA genotype. These data consistent functional relevance allelic regulation expression miRNA let-7 cells. Stratified analyses elucidated statistically significant existed either astrocytic tumors (P 6.3 oligoastrocytic 0.002). In conclusion, our results support hypothesis genetic variants influencing miRNA-mediated tumor suppressor genes oncogenes may contribute susceptibility.