Gestational stage-specific effects of retinoic acid exposure in the rat.

摘要: Although, or perhaps because, retinoids are among the earliest known behavioral teratogens, there is still little agreement about effects of stage-specific exposure to these compounds. In studies, pregnant albino rats were gavaged once daily with retinoic acid (RA) for 3 consecutive gestational days (GD), GD 8-10), 11-13, 14-16. Dose levels maximal compatible survival (10, 2.5, 12.5 mg/kg RA, over 8-10, and 14-16, respectively). Two studies conducted. The first assessed RA on 8-10 14-16 regional brain weight a large test battery. second study 11-13 many same variables. Taken together an earlier exposure, permit following conclusions. 1) at above doses any three periods produced apparent reduction in amphetamine-induced open field activity. 2) but not robust, replicable rotarod deficit exposed offspring. 3) later, increased daytime activity residential running wheels. 4) reduced cerebellum. 5) No effect period was seen maze learning, novel fields, auditory startle.