Detection of recurrent head and neck squamous cell carcinomas after radiation therapy with 2-18F-fluoro-2-deoxy-D-glucose positron emission tomography

摘要: Objectives/Hypothesis: Fluorodeoxyglucose positron emission tomography (FDG-PET) has been proposed as a sensitive method to diagnose and stage various malignancies. We assessed the efficacy of FDG-PET imaging in distinguishing tumor persistence/recurrence from posttreatment changes following radiation therapy for squamous carcinomas head neck. Study Design: Retrospective analysis IDG-PET results compared with biopsy or outcome, both. Methods: Twenty-eight patients who had undergone without surgery treatment cell carcinoma were studied imaging. There was clinical suspicion recurrence each patient, but no obvious mass lesion found on physical examination anatomic The those follow-up at least 6 months, Results: positive 13 patients, presence active disease confirmed 12. Two thirds 12 received further cancer treatment. 15 negative images. Thirteen these true-negative images, two studies false-negative sensitivity specificity 86% 93%, respectively, predictive values 92% 87%, respectively. overall accuracy 89%. Conclusion: is useful modality distinguish radiation-induced tissue neck cancer. can identify may benefit treatment, lead improved outcome individual patients. Key Words: Fluorodeoxyglucose; cancer: tomography; carcinoma.