Age-related effect of aerobic exercise training on antioxidant and oxidative markers in the liver challenged by doxorubicin in rats.
作者： Mehdi Ahmadian , Valiollah Dabidi Roshan , Anthony S. Leicht
DOI: 10.1080/10715762.2018.1470328
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摘要: AbstractThe aims of the current study were to investigate oxidant and antioxidant status liver tissue challenged by doxorubicin examine possible protective effects aerobic exercise on doxorubicin-induced oxidative stress. Seventy-two rats divided into three age groups (Young, Adult, Elderly) with treatment subgroups consisting eight per group: doxorubicin, exercise + doxorubicin, exercise + saline. The experimental performed regular treadmill running for 3 weeks. Doxorubicin was administered i.p. injection at a dosage 20 mg kg−1 while exercise + saline group received saline comparable volume. Heat shock protein 70, malondialdehyde, glutathione peroxidase, carbonyl determined from homogenates following intervention period. Treatment induced hepatotoxicity in all lower values stress young compared older groups. inclusion of...
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