Topographic thickness of Bowman's layer determined by ultra-high resolution spectral domain-optical coherence tomography

摘要: Bowman's layer and the basal lamina are important in maintenance support of ocular surface.1 For instance, integrity prevent eyes from developing persistent epithelial defects after transplantation.2 Additionally, a cellular proliferative response initiated by disruption occurs advanced bullous keratopathy.1 Recently, characteristics central peripheral layer, close to limbus, have drawn increased clinical attention, especially for designing refractive surgery detecting corneal disease. A variety techniques been used assess both healthy diseased human corneas.3–5 However, each these methods has some limitations. Confocal microscopy is an invasive technique with potential causing lesions or transmitting infections, it impossible measure exactly same locations within cornea serial examinations. Electron allows only histopathologic findings. Thus, there few published characterizations at periphery, limbus. Recent advances optical coherence tomography (OCT) enabled exact rapid cross-sectional imaging without direct contact between eye instrument. OCT excellent repeatability accuracy.6–8 Spectral domain (SD-OCT) that enhanced resolution compared conventional time OCT. The high-speed modality enables analysis topographic thickness epithelium, stroma, total cornea. purpose this study was evaluate ultra-high SD-OCT profile along horizontal meridian eyes.