Dipeptidyl peptidase in autoimmune pathophysiology.
作者： Kei Ohnuma , Osamu Hosono , Nam H. Dang , Chikao Morimoto
DOI: 10.1016/B978-0-12-385855-9.00003-5
关键词:
摘要: CD26 is a 110-kDa surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) activity that expressed on various cell types and has many biological functions. An important aspect of biology its functional physical association molecules key roles in human immunological programs. role immune regulation been extensively characterized, recent findings elucidating link age signaling pathways structures involved T activation well as antigen-presenting cell-T interaction, being marker diseas behavior clinically playing an autoimmune pathogenesis development. Through the use experimental approaches agents to influence CD26/DPPIV expression activity, such anti-CD26 antibodies, chemical inhibitors, siRNAs inhibit expression, overexpressing transfectants, soluble proteomic approach, we have shown interacts essential cellular functions responses. We will review emerging data suggest may be appropriate therapeutic target for treatment selected disorders.
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