Pathophysiology of Vesicle Dynamics in Astrocytes

摘要: In astrocytes, as in other eukaryotic cells, vesicles have key cellular functions including constitutive housekeeping of the plasma membrane structure and cell-to-cell communication. On one hand, vesicle traffic is associated with cell surface morphology exhibiting distinct glial microdomains. These determine signaling potential metabolic support for neighboring cells. are used astrocytes release vesicle-laden chemical messengers. This chapter addresses properties membrane-bound that store gliotransmitters (glutamate, adenosine 5’-triphosphate, peptides), recycling vesicles, endocytotic involved receptors such class II major histocompatibility molecules transporters (aquaporin 4 excitatory amino acid transporter 2). Vesicle dynamics also considered view diseases amyotrophic lateral sclerosis, multiple autistic disorders, trauma, edema, states which contribute to neuroinflammation. example, fingolimod, a recently introduced drug, apparently affects gliotransmitter from indicating these processes may well be target development new therapies.