The crucial role of multiomic approach in cancer research and clinically relevant outcomes
作者： Miaolong Lu , Xianquan Zhan
DOI: 10.1007/S13167-018-0128-8
关键词:
摘要: Cancer with heavily economic and social burden is the hot point in field of medical research. Some remarkable achievements have been made; however, exact mechanisms tumor initiation development remain unclear. a complex, whole-body disease that involves multiple abnormalities levels DNA, RNA, protein, metabolite imaging. Biological omics including genomics, transcriptomics, proteomics, metabolomics radiomics aims to systematically understand carcinogenesis different biological levels, which driving shift cancer research paradigm from single parameter model multi-parameter systematical model. The rapid various technologies one conveniently get multi-omics data, accelerates predictive, preventive personalized medicine (PPPM) practice allowing prediction response substantially increased accuracy, stratification particular patients eventual personalization medicine. This review article describes methodology, advances, clinically relevant outcomes “omics” research, especially emphasizes importance scientific merit integrating outcomes.
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