Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer
作者： Xiaoxiang Guan , Hui Zhao , Jiangong Niu , Dongfeng Tan , Jaffer A Ajani
关键词:
摘要: Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes involved in tumor growth progression including angiogenesis, dissemination, invasiveness, we hypothesized would associated with survival patients gastric cancer. We genotyped -509 C>T, +1869 T>C, +915 G>C -1498T>C, -634G>C, +936C>T 167 Using the Kaplan Meier method, log-rank tests, Cox proportional hazard models, evaluated associations among variants overall, 1-year, 2-year rates. Although there were no significant differences overall rates all tested, TGFB1+915CG CC genotypes had a poorer (adjusted ratio (HR), 3.06; 95% confidence interval (CI), 1.09–8.62; P = 0.034) than GG genotype had. In addition, heterozygous for -634CG also 1-year HR, 2.08; CI, 1.03–4.22; 0.042) -634GG genotype. Our study suggested TGFB1+915CG/CC may short-term cancer patients. However, larger studies needed verify findings.
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Du-Hu Liu, Expression of vascular endothelial growth factor and its role in oncogenesis of human gastric carcinoma World Journal of Gastroenterology. ,vol. 7, pp. 500- 505 ,(2001) , 10.3748/WJG.V7.I4.500
Kyoung-Mu Lee, Sue Kyung Park, Nobuyuki Hamajima, Kazuo Tajima, Keun-Young Yoo, Aesun Shin, Dong-Young Noh, Sei-Hyun Ahn, Ari Hirvonen, Daehee Kang, Genetic polymorphisms of TGF-β1 & TNF-β and breast cancer risk Breast Cancer Research and Treatment. ,vol. 90, pp. 149- 155 ,(2005) , 10.1007/S10549-004-3859-2
Nikolaos Tzanakis, Maria Gazouli, George Rallis, George Giannopoulos, Ioannis Papaconstantinou, George Theodoropoulos, Emmanouil Pikoulis, Christos Tsigris, Petros Karakitsos, George Peros, Nikolaos Nikiteas, Vascular endothelial growth factor polymorphisms in gastric cancer development, prognosis, and survival Journal of Surgical Oncology. ,vol. 94, pp. 624- 630 ,(2006) , 10.1002/JSO.20619
Guo-yang Wu, Till Hasenberg, Richard Magdeburg, Roderich Bönninghoff, Jörg W. Sturm, Michael Keese, Association between EGF, TGF-β1, VEGF gene polymorphism and colorectal cancer. World Journal of Surgery. ,vol. 33, pp. 124- 129 ,(2009) , 10.1007/S00268-008-9784-5
R Zhai, M N Gong, W Zhou, T B Thompson, P Kraft, L Su, D C Christiani, Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS. Thorax. ,vol. 62, pp. 718- 722 ,(2007) , 10.1136/THX.2006.069393
Sonia B. Jakowlew, Transforming growth factor-β in cancer and metastasis Cancer and Metastasis Reviews. ,vol. 25, pp. 435- 457 ,(2006) , 10.1007/S10555-006-9006-2
M. Suthanthiran, Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 3479- 3484 ,(2000) , 10.1073/PNAS.050420897
Brian Bierie, Harold L. Moses, Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer Nature Reviews Cancer. ,vol. 6, pp. 506- 520 ,(2006) , 10.1038/NRC1926
Douglas Hanahan, Judah Folkman, Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis Cell. ,vol. 86, pp. 353- 364 ,(1996) , 10.1016/S0092-8674(00)80108-7
Guangfu Jin, Lina Wang, Wensen Chen, Zhibin Hu, Yan Zhou, Yongfei Tan, Jianming Wang, Zhaolai Hua, Weiliang Ding, Jing Shen, Zuofeng Zhang, Xinru Wang, Yaochu Xu, Hongbing Shen, Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population International Journal of Cancer. ,vol. 120, pp. 1330- 1335 ,(2007) , 10.1002/IJC.22443