Cardiovascular and Endocrine Properties of L-Tryptophan in Combination with Various Diets

摘要: Brain serotonin neurons are intimately involved in a number of relevant physiological functions such as cardiovascular regulation, neuroendocrine output from the anterior pituitary (e.g. ACTH, prolactin), regulation behavior agression, sleep, locomotor and sexual behavior), mood or appetite control (Fernstrom, 1983; Lehnert et al., 1987; Spring Wurtman, 1987). The synthesis brain is dependent on availability large neutral amino acid L-tryptophan that hydroxylated to 5-L-hydroxytryptophan subsequently decarboxylated yield serotonin. rate-limiting enzyme tryptophan hydroxylase has Michaelis constant approximately 2–3 x 10−5 M with tetrahydrobiopterin used cofactor (Tong Kaufmann, 1975) thus approximates normal concentrations about 1–5 M. Therefore, not saturated under circumstances an increased will lead enhanced (Fernstrom 1971; Fernstrom, 1983).