Transcriptional regulation of Mcl-1 plays an important role of cellular protective effector of vincristine-triggered autophagy in oral cancer cells.
作者： Ming-Ju Hsieh , Yi-Hsien Hsieh , Chiao-Wen Lin , Mu-Kuan Chen , Shun-Fa Yang
DOI: 10.1517/14728222.2014.998200
关键词:
摘要: Objective: The autophagy-associated release of HMGB1 (high-mobility group box 1) has been reported that protect cancer cells from numerous chemotherapeutics. However, the related molecular mechanism involved in protection oral remains unclear.Research design and methods: In this study, we determined released by protected against apoptosis caused vincristine upregulating transcription Mcl-1.Results: Extracellular seems to be required for autophagy-mediated inhibition because effect autophagy was abolished knockdown. Vincristine treatment increased expression Mcl-1 mRNA, but decreased protein expression. inhibited blocked increase reduced expression, demonstrate is upregulation transcriptional, thereby maintaining levels survival ora...
sci-hub.se 参考文章(39)
Devrim Gozuacik, Adi Kimchi, Autophagy and Cell Death Current Topics in Developmental Biology. ,vol. 78, pp. 217- 245 ,(2007) , 10.1016/S0070-2153(06)78006-1
Peter Hersey, Xu Dong Zhang, Overcoming resistance of cancer cells to apoptosis. Journal of Cellular Physiology. ,vol. 196, pp. 9- 18 ,(2003) , 10.1002/JCP.10256
Susanne Müller, Paola Scaffidi, Bernard Degryse, Tiziana Bonaldi, Lorenza Ronfani, Alessandra Agresti, Monica Beltrame, Marco E Bianchi, The double life of HMGB1 chromatin protein: architectural factor and extracellular signal The EMBO Journal. ,vol. 20, pp. 4337- 4340 ,(2001) , 10.1093/EMBOJ/20.16.4337
Julian J. Lum, Daniel E. Bauer, Mei Kong, Marian H. Harris, Chi Li, Tullia Lindsten, Craig B. Thompson, Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell. ,vol. 120, pp. 237- 248 ,(2005) , 10.1016/J.CELL.2004.11.046
Jacqueline Thorburn, Arthur E. Frankel, Andrew Thorburn, Regulation of HMGB1 release by autophagy Autophagy. ,vol. 5, pp. 247- 249 ,(2009) , 10.4161/AUTO.5.2.7552
Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S. Maser, Bo Zhai, Lixin Wan, Alejandro Gutierrez, Alan W. Lau, Yonghong Xiao, Amanda L. Christie, Jon Aster, Jeffrey Settleman, Steven P. Gygi, Andrew L. Kung, Thomas Look, Keiichi I. Nakayama, Ronald A. DePinho, Wenyi Wei, SCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction Nature. ,vol. 471, pp. 104- 109 ,(2011) , 10.1038/NATURE09732
K E Tagscherer, A Fassl, B Campos, M Farhadi, A Kraemer, B C Böck, S Macher-Goeppinger, B Radlwimmer, O D Wiestler, C Herold-Mende, W Roth, Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins. Oncogene. ,vol. 27, pp. 6646- 6656 ,(2008) , 10.1038/ONC.2008.259
Ingrid E. Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J. Anderson, Elizabeth Helgason, James A. Ernst, Mike Eby, Jinfeng Liu, Lisa D. Belmont, Joshua S. Kaminker, Karen M. O’Rourke, Kanan Pujara, Pawan Bir Kohli, Adam R. Johnson, Mark L. Chiu, Jennie R. Lill, Peter K. Jackson, Wayne J. Fairbrother, Somasekar Seshagiri, Mary J. C. Ludlam, Kevin G. Leong, Erin C. Dueber, Heather Maecker, David C. S. Huang, Vishva M. Dixit, Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 Nature. ,vol. 471, pp. 110- 114 ,(2011) , 10.1038/NATURE09779
Michael T. Lotze, Kevin J. Tracey, High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nature Reviews Immunology. ,vol. 5, pp. 331- 342 ,(2005) , 10.1038/NRI1594
Rui Kang, Kristen M Livesey, Herbert J Zeh, III, Michael T Lotze, Daolin Tang, None, HMGB1 as an autophagy sensor in oxidative stress. Autophagy. ,vol. 7, pp. 904- 906 ,(2011) , 10.4161/AUTO.7.8.15704