The Nuclear Receptor DHR3 Modulates dS6 Kinase–Dependent Growth in Drosophila

作者: Jacques Montagne , Caroline Lecerf , Jean-Philippe Parvy , Janis M. Bennion , Thomas Radimerski

DOI: 10.1371/JOURNAL.PGEN.1000937

关键词:

摘要: S6 kinases (S6Ks) act to integrate nutrient and insulin signaling pathways and, as such, function positive effectors in cell growth organismal development. However, they also have been shown play a key role limiting mediating the autophagic response. To identify novel regulators of S6K signaling, we used Drosophila-based, sensitized, gain-of-function genetic screen. Unexpectedly, one strongest enhancers emerge from this screen was nuclear receptor (NR), Drosophila hormone 3 (DHR3), critical constituent coordination metamorphosis. Here demonstrate that DHR3, through dS6K, acts regulate cell-autonomous growth. Moreover, show ligand-binding domain (LBD) DHR3 is essential for Consistent with these findings, identified an endogenous isoform lacks DBD. These results provide first molecular link between dS6K pathway, controlling nutrient-dependent growth, major mediator ecdysone which, acting together, coordinate

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