Methylenetetrahydrofolate Reductase Polymorphism C677T Is a Protective Factor for Pediatric Acute Lymphoblastic Leukemia in the Chinese Population: A Meta-Analysis
作者： Haigang Wang , Lujing Meng , Lixia Zhao , Jiali Wang , Xinchun Liu
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摘要: Two polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, were hypothesized to decrease risk of acute lymphoblastic leukemia (ALL). Studies examining associations between these two ALL susceptibility drew inconsistent results. To obtain a reliable conclusion Chinese population, we carried out meta-analysis. In total, 11 studies on polymorphism (1597 cases 2295 controls) 10 A1298C (1553 2224 included We found significant association 677T variant reduced children (Dominant model: odds ratio [ORFE]=0.73, 95% confidence interval [CI]: 0.63–0.86, p 0.1). adult subgroup, there was no ...
sci-hub.se 参考文章(25)
Ling Lv, Cuie Wu, Henjuan Sun, Saijuan Zhu, Yongchen Yang, Xi Chen, Hua Fu, Liming Bao, Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR ) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population European Journal of Haematology. ,vol. 84, pp. 506- 512 ,(2010) , 10.1111/J.1600-0609.2010.01430.X
Gideon Friedman, Netta Goldschmidt, Yechiel Friedlander, Arie Ben-Yehuda, Jacob Selhub, Sharona Babaey, Malka Mendel, Miriam Kidron, Hanoch Bar-On, A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. Journal of Nutrition. ,vol. 129, pp. 1656- 1661 ,(1999) , 10.1093/JN/129.9.1656
Allen Eng-Juh Yeoh, Yi Lu, Jason Yong-Sheng Chan, Yiong Huak Chan, Hany Ariffin, Shirley Kow-Yin Kham, Thuan Chong Quah, Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leukemia Research. ,vol. 34, pp. 276- 283 ,(2010) , 10.1016/J.LEUKRES.2009.07.003
Ilan S Weisberg, Paul F Jacques, Jacob Selhub, Andrew G Bostom, Zhoutao Chen, R Curtis Ellison, John H Eckfeldt, Rima Rozen, The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis. ,vol. 156, pp. 409- 415 ,(2001) , 10.1016/S0021-9150(00)00671-7
Na Tong, Xiaojing Sheng, Meilin Wang, Yongjun Fang, Danni Shi, Zhizhong Zhang, Zhengdong Zhang, Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis based on 28 case-control studies. Leukemia & Lymphoma. ,vol. 52, pp. 1949- 1960 ,(2011) , 10.3109/10428194.2011.589545
Ghislaine Scélo, Catherine Metayer, Luoping Zhang, Joseph L. Wiemels, Melinda C. Aldrich, Steve Selvin, Stacy Month, Martyn T. Smith, Patricia A. Buffler, Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environmental Health Perspectives. ,vol. 117, pp. 133- 139 ,(2009) , 10.1289/EHP.11927
Jennifer L. McNeer, The complex interplay between folate metabolism and risk of acute lymphoblastic leukemia. Leukemia & Lymphoma. ,vol. 52, pp. 1621- 1622 ,(2011) , 10.3109/10428194.2011.591010
Jingrong Yan, Ming Yin, ZoAnn E. Dreyer, Michael E. Scheurer, Kala Kamdar, Qingyi Wei, M. Fatih Okcu, A meta-analysis ofMTHFRC677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children Pediatric Blood & Cancer. ,vol. 58, pp. 513- 518 ,(2012) , 10.1002/PBC.23137
Jing Wang, Ping Zhan, Bing Chen, Rongfu Zhou, Yonggong Yang, Jian Ouyang, MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis Leukemia Research. ,vol. 34, pp. 1596- 1600 ,(2010) , 10.1016/J.LEUKRES.2010.03.034
L Krishnamoorthy, N Ramachandra, L Appaji, BS Aruna Kumari, G Ramaswamy, HS Savithri, MN Sadananda Adiga, S Chandy, Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children Indian Journal of Cancer. ,vol. 47, pp. 40- 45 ,(2010) , 10.4103/0019-509X.58858