METHODS OF USE OF ALPHA-METHYLACYL-CoA RACEMASE IN HORMONE REFRACTORY AND METASTATIC PROSTATE CANCERS

摘要: Methods for identifying patients having or at risk of developing prostate cancer (including hormone refractory androgen independent cancer) and a arising from metastasis if to another tissue, e.g., liver lymph node, by measuring the expression activity alpha-methylacyl-CoA racemase are described. The invention also provides: methods screening compounds that can be used treat metastases modulate polypeptides nucleic acids; process modulating (i.e., reducing) polypeptide acid activity, using screened compounds; selecting therapy with compound reduces as well determining whether such should continued in patient.