Surveillance in Barrett's esophagus: an audit of practice.

作者: Adewale Ajumobi , Khaled Bahjri , Christian Jackson , Ronald Griffin

DOI: 10.1007/S10620-009-0917-Y

关键词:

摘要: Determine the rates of follow-up, incident rate cancer during surveillance, and changes in pathologic grade patients with Barrett’s esophagus surveillance a gastroenterology practice without formal program. is pre-malignant condition. Surveillance endoscopy (SE) recommended order to detect treat high-grade dysplasia esophageal adenocarcinoma early prevent deaths. SE has not been shown have mortality benefit several studies questioned its cost-effectiveness. Most practices do program for esophagus. The few that exist are only very specialized funded programs. Little information exists on outcomes outside these well-structured A retrospective analysis cohort diagnosed surveyed between 1995 2005 at Veterans Affairs medical center. Data were collected age, body mass index, race. Patients who missed their by 6 months or more those twice intervals identified analyzed grades. total 472 had 2005. Three hundred five one biopsy. They did follow-up endoscopies biopsies. Two excluded from final analysis: an esophagectomy after index diagnosis dysplasia, 2 days initial impression There 165 metaplasia than once included analysis. Overall, 53.3% no change grade, 35.2% regressed lower 11.5% progressed higher grade. None (0/165, 0%) adenocarcinoma; 3.6% (6/165) (19/165) normal mucosa. Forty-four more. Of these, 50% regressed, 40.9% change, 9.1% progressed. Four mucosa, none adenocarcinoma. Twenty-three 60.9% 34.8% 4.3% but three After adjusting age low-grade nearly seven times likely miss (OR 6.56, P-value 0.03). veteran undergo endoscopies. Veteran undergoing rarely progress longer up because they scheduled worse outcome when compared general group. most more, though reason this unknown.

参考文章(42)
Lybus C Hillman, Louise Chiragakis, Graham L Kaye, Anthony C Clarke, Bruce Shadbolt, Proton-pump inhibitor therapy and the development of dysplasia in patients with Barrett’s oesophagus The Medical Journal of Australia. ,vol. 180, pp. 387- 391 ,(2004) , 10.5694/J.1326-5377.2004.TB05991.X
Provenzale D, Wong Jb, Arora S, Kemp Ja, A guide for surveillance of patients with Barrett's esophagus. The American Journal of Gastroenterology. ,vol. 89, pp. 670- 680 ,(1994)
Regression of Barrett's epithelium with omeprazole. The New England Journal of Medicine. ,vol. 320, pp. 1497- 1498 ,(1989) , 10.1056/NEJM198906013202218
Rodger C. Haggitt, Joan Tryzelaar, F. Henry Ellis, Henry Colcher, Adenocarcinoma Complicating Columnar Epithelium-lined (Barrett’s) Esophagus American Journal of Clinical Pathology. ,vol. 70, pp. 1- 5 ,(1978) , 10.1093/AJCP/70.1.1
Bergein F Overholt, Charles J Lightdale, Kenneth K Wang, Marcia I Canto, Steven Burdick, Roger C Haggitt, Mary P Bronner, Shari L Taylor, Michael GA Grace, Michelle Depot, International Photodynamic Group for High-Grade Dysplasia in Barrett's Esophagus, None, Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial. Gastrointestinal Endoscopy. ,vol. 62, pp. 488- 498 ,(2005) , 10.1016/J.GIE.2005.06.047
T A Wright, M R Gray, A I Morris, I T Gilmore, A Ellis, H L Smart, M Myskow, J Nash, R J Donnelly, A N Kingsnorth, Cost effectiveness of detecting Barrett's cancer. Gut. ,vol. 39, pp. 574- 579 ,(1996) , 10.1136/GUT.39.4.574
John M. Inadomi, Richard Sampliner, Jesper Lagergren, David Lieberman, A Mark Fendrick, Nimish Vakil, Screening and Surveillance for Barrett Esophagus in High-Risk Groups: A CostUtility Analysis Annals of Internal Medicine. ,vol. 138, pp. 176- 186 ,(2003) , 10.7326/0003-4819-138-3-200302040-00009
Nicholas J. Shaheen, Melissa A. Crosby, Eugene M. Bozymski, Robert S. Sandler, Is there publication bias in the reporting of cancer risk in Barrett's esophagus? Gastroenterology. ,vol. 119, pp. 333- 338 ,(2000) , 10.1053/GAST.2000.9302
Erinn Downs-Kelly, Joel E. Mendelin, Ana E. Bennett, Elias Castilla, Walter H. Henricks, Lynn Schoenfield, Marek Skacel, Lisa Yerian, Thomas W. Rice, Lisa A. Rybicki, Mary P. Bronner, John R. Goldblum, Poor interobserver agreement in the distinction of high-grade dysplasia and adenocarcinoma in pretreatment Barrett's esophagus biopsies. The American Journal of Gastroenterology. ,vol. 103, pp. 2333- 2340 ,(2008) , 10.1111/J.1572-0241.2008.02020.X