New trends in the development of opioid peptide analogues as advanced remedies for pain relief.

摘要: The search for new peptides to be used as analgesics in place of morphine has been mainly directed develop peptide analogues or peptidomimetics having higher biological stability and receptor selectivity. Indeed, most the alkaloid opioid counterindications are due scarce contemporary activation different types. However, development several extremely stable selective ligands receptors, recent discovery micro-receptor endomorphins, rendered this less fundamental. In years, other properties have investigated pharmacological tools. utility a drug depends on its ability reach appropriate receptors at target tissue remain metabolically order produce desired effect. This review deals with investigations bioavailability, particular barrier penetration resistance against enzymatic degradation; activity receptors; chimeric peptides, propeptides, non-conventional lacking basic pharmacophoric features.