An association between optic glioma and other tumours of the central nervous system in neurofibromatosis type 1.

摘要: Neurofibromatosis type 1 (NF1) has a very heterogeneous phenotype. It is not currently possible to predict which patients will have mild disease and develop serious complications. Medical management of with NF1 might be improved if subgroups who are at especially high (or low) risk for particular complications could identified. We begun an analysis in the National Foundation International Database (NNFFID) identify associations between occurrence clinical features. A striking association been observed presence optic glioma other central nervous system (CNS) tumours patients. This dependent on effect age. No seen non-CNS neoplasms. The intracranial neoplasms suggests that there fundamental pathophysiological differences without glioma.