EndothelinA-endothelinB receptor cross-talk and endothelin receptor binding

摘要: Background and objective  The magnitude of inhibition an endothelin (ET)-1 response by selective blockade the ETA or ETB receptors can be limited apparent compensation mediated unblocked receptor. While mechanism underlying this functionally defined interaction, ‘cross-talk’, is not clear, binding studies suggest interaction between ET receptor subtypes. Key findings  These are reviewed that, in general, they support hypothesis that activation intracellular signalling pathways influence ET-1 to these subtypes. Summary  However, relationship functional effects and, thus, ETA-ETB cross-talk, remains largely untested.