Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.

作者: Jacob Richards , Amanda K. Welch , Sarah J. Barilovits , Sean All , Kit-Yan Cheng

DOI: 10.1016/J.LFS.2014.03.028

关键词:

摘要: Aims The present study is designed to consider a role for the circadian clock protein Per1 in regulation of endothelin axis mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) regulator epithelial sodium channel (ENaC) blood pressure (BP), via activation both receptors, ETA ETB. However, ET-1 mediates many complex events other tissues.

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