Endothelin and endothelin receptors in the renal and cardiovascular systems

摘要: Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic vascular resistance, salt water reabsorption, glomerular function. responsible for variety cellular events: contraction, proliferation, apoptosis, etc. These effects take place after activation two endothelin receptors ET(A) ET(B), are present - among others on cardiomyocytes, fibroblasts, smooth muscle endothelial cells, tubular cells kidney. The complex numerous intracellular pathways, can be contradictory in term functional response depending receptor type, cell type physiological situation, described this review. Many diseases share an enhanced expression as part pathophysiology. However, use blockers currently restricted to pulmonary arterial hypertension, more recently digital ulcer. complexity system does not facilitate translation molecular knowledge clinical applications. Endothelin antagonists prevent disease development but secondary undesirable limit their usage. Nevertheless, increasing understanding maintains promising therapeutic target.