Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review

摘要: The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control, and is implicated the pathogenesis of hypertension. Polymorphisms within this gene have been extensively studied association with hypertension; however, findings are conflicting. To clarify these data, we conducted a systematic review studies AGTR1 polymorphisms hypertension, performed meta-analysis rs5186 variant. Results show that currently available literature too heterogeneous to draw meaningful conclusions. definition hypertension gender composition individual helps explain heterogeneity. Although structure splicing pattern would suggest likely effect promoter region on function, few thus far. In conclusion, there insufficient evidence risk factors for However, most inadequately powered, larger well-designed haplotypes warranted.