Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives.

摘要: BACKGROUND A silent polymorphism (+1166 A/C single-nucleotide polymorphism) localized in the 3'-UTR (untranslated region) of human angiotensin II type-1 receptor (AT1 R) has been associated with hypertension and cardiovascular complications.The +1166 is recognized by a specific microRNA-155 (miR-155), which base-pairing complementary A-allele but not mutant C allele. Aim our study was to investigate interplay between miR-155 AT1 R protein expression. METHODS Sixty-four subjects were selected for from cohort hypertensives (n = 573) Hypertension Ambulatory Recording Venetia Study (HARVEST): 25 homozygous 1166 allele, 20 heterozygous, 19 1166C RESULTS expression significantly decreased CC genotype comparison AA AC genotype. increased group (P < 0.01) although mRNA different three groups. positively correlated systolic diastolic blood pressure negatively level. Plasma transforming growth factor-β1 (TGF-β1) may have modulator role as it CONCLUSION The expression, +1166C polymorphism, regulation pressure.