Effects of artemisinin-based combination therapy on histopathology of the liver, kidney and spleen of mice infected with Plasmodium berghei

摘要: Malaria has remained one of the leading causes morbidity and mortality in most developing countries. Artemisinin-based combination therapy (ACT) had been adopted for management disease. This study evaluated effects therapeutic doses artesunate + amodiaquine dihydroartemisnin piperaquine on liver, kidney spleen mice infected with Plasmodium berghei. Sixty adult eight weeks old average weight 22.5 ± 5.5 g were randomly divided into six groups ten animals each. berghei was inoculated observed seven days, followed by three days oral administration (AA periportal inflammatory cells, haemopoietic precursor haemozoin pigmentation liver untreated treated groups. The showed pigments, loss typical structure germinal centre, apoptotic lymphocytes tinged macrophages, megakaryocytes cells Inflammation renal pelvis found group dihydroartemisinin piperaquine. Cytoplasmic vacuolation after 28 follow-up. infection treatment (A&A) caused reversible damages to kidney. Keywords : Malaria, Artemisinin, Liver, Spleen, Kidney,