Effects of Parenteral Application of Fish Oil versus Soy Oil Emulsions on Bacterial Clearance Functions

摘要: Background: The aim of this study was to test whether or not infusion triglycerides containing ω-3 fatty acids (FAs) modifies immune function in terms systemic clearance and organ distribution injected Escherichia coli a rabbit model. Materials Methods: In groups 6 rabbits each, defined number E. (1.3 × 108 colony-forming units, CFU) intravenously after 3 days with lipid emulsion prepared from fish oil (Omegavenos® 10%, 1.5 g/kg body weight/day), soy preparation (Lipovenos® isotonic saline application (control). order compare dose-dependent effects, second experimental design lower dose each (0.5 weight) infused over 4-hour period before applicating . Parameters monitored were arterial pressure rates bacterial elimination the blood. animals killed h infection, respectively, tissue samples liver, spleen, lung, kidney collected for microbiological examinations. Results: Lipovenos produced significant delay blood compared Omegavenos treatment. diminished accompanied by increased numbers af viable bacteria lung spleen. contrast this, group counts did increase smaller amounts detected homogenates injection Conclusion: Compared preparation, FAs induce improved that is associated significantly lung. Thus, appropriate nutrition providing FA might serve as pharmacological tool improve host defence against infection critically ill patients.