Effects of Hemorrhage on Inflammatory Response
作者： Edward Abraham
DOI: 10.1001/ARCHSURG.1984.01390220040009
关键词: Blood volume 、 Autologous blood 、 Inflammatory response 、 Carotid arteries 、 Inflammation 、 Surgery 、 Vasoconstriction 、 Anesthesia 、 Medicine 、 Depression (differential diagnoses)
摘要: • Bacterial infection often occurs after trauma and hemorrhage is believed to be a reflection of compromised host defense system. In the present study, we investigated effect temporary loss blood on integrity inflammatory response. Hemorrhage was induced in rats that had long-term carotid artery catheterizations autologous returned animals two hours later. The development carrageenan-induced inflammation suppressed volume-dependent manner. After withdrawal 30% total volume response decreased 82%, remained for at least 24 hours. degree depression also found dependent time elapsed before retransfusion. Vasoconstriction by hypovolemic stress does not appear cause posthemorrhage suppression (Arch Surg1984;119:1154-1157)
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