Effects of digoxin on cell cycle, apoptosis and NF-κB pathway in Burkitt’s lymphoma cells and animal model

作者: Ting Wang , Peipei Xu , Fan Wang , Di Zhou , Ruju Wang

DOI: 10.1080/10428194.2016.1256480

关键词:

摘要: Digoxin has potential antitumor properties. This study investigated whether digoxin suppressed Burkitt’s lymphoma (BL) cells. Raji and NAMALWA cells were exposed to digoxin, followed by assay of ce...

参考文章(38)
Ruo-Wen Huang, Ming-Juan Zhang, Ting Zhang, Yan-Ping Ren, Dual effects of ouabain on the regulation of proliferation and apoptosis in human umbilical vein endothelial cells: involvement of Na(+)-K(+)-ATPase α-subunits and NF-κB. International Journal of Clinical and Experimental Medicine. ,vol. 7, pp. 1214- 1222 ,(2014)
Fares Nigim, Jill Cavanaugh, Anoop P. Patel, William T. Curry, Shin-ichi Esaki, Ekkehard M. Kasper, Andrew S. Chi, David N. Louis, Robert L. Martuza, Samuel D. Rabkin, Hiroaki Wakimoto, Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. Journal of Neuropathology and Experimental Neurology. ,vol. 74, pp. 710- 722 ,(2015) , 10.1097/NEN.0000000000000210
Sheng-Yi Lin, Hsiu-Hui Chang, Yi-Hua Lai, Ching-Hsiung Lin, Min-Hsuan Chen, Gee-Chen Chang, Meng-Feng Tsai, Jeremy J. W. Chen, Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer PLOS ONE. ,vol. 10, pp. e0123305- ,(2015) , 10.1371/JOURNAL.PONE.0123305
Roberta Zappasodi, Alessandra Cavanè, Marilena V. Iorio, Monica Tortoreto, Carla Guarnotta, Giusi Ruggiero, Claudia Piovan, Michele Magni, Nadia Zaffaroni, Elda Tagliabue, Carlo M. Croce, Franco Zunino, Alessandro M. Gianni, Massimo Di Nicola, Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas International Journal of Cancer. ,vol. 135, pp. 2034- 2045 ,(2014) , 10.1002/IJC.28852
Ben Boursi, Kevin Haynes, Ronac Mamtani, Yu-Xiao Yang, Digoxin use and the risk for colorectal cancer Pharmacoepidemiology and Drug Safety. ,vol. 23, pp. 1147- 1153 ,(2014) , 10.1002/PDS.3717
Hasan Kirmizibekmez, Milena Masullo, Michela Festa, Anna Capasso, Sonia Piacente, Steroidal glycosides with antiproliferative activities from Digitalis trojana. Phytotherapy Research. ,vol. 28, pp. 534- 538 ,(2014) , 10.1002/PTR.5012
Erle S Robertson, None, Burkitt's lymphoma The Lancet. ,vol. 379, pp. 1234- 1244 ,(2012) , 10.1016/S0140-6736(11)61177-X
Dinara Daniel, Caner Süsal, Brigitte Kopp, Gerhard Opelz, Peter Terness, Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives International Immunopharmacology. ,vol. 3, pp. 1791- 1801 ,(2003) , 10.1016/J.INTIMP.2003.08.004
Katarzyna Winnicka, Krzysztof Bielawski, Anna Bielawska, Wojciech Miltyk, Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells Archives of Pharmacal Research. ,vol. 30, pp. 1216- 1224 ,(2007) , 10.1007/BF02980262
Anh-Nguyet T. Nguyen, Kyle Jansson, Gladis Sánchez, Madhulika Sharma, Gail A. Reif, Darren P. Wallace, Gustavo Blanco, Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation. American Journal of Physiology-renal Physiology. ,vol. 301, ,(2011) , 10.1152/AJPRENAL.00095.2011