Prognostic significance of calcium-binding protein S100A4 in colorectal cancer
作者： Silvia Gongoll , Gerrit Peters , Michael Mengel , Pompiliu Piso , Jürgen Klempnauer
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摘要: Abstract Background & Aims: Prognostication in colon cancer almost exclusively still rests on the tumor stage. Furthermore, tumor-derived markers to improve discrimination of low- and high-risk subtypes generally are not use. S100A4 has been reported be associated with invasion metastasis; however, no data available its prognostic value colorectal carcinoma. Therefore, we investigated significance immunohistochemical expression carcinoma compared clinicopathologic parameters cell-cycle p16, p21, p27, p53, Ki-67, RB. Methods: Archival tissue from 709 patients were retrieved, applied array technology, immunohistochemically. Univariate multivariate survival analyses carried out all parameters. Results: Sixteen percent cases showed high; 31%, low; 53%, expression. In Kaplan–Meier analysis, positively stained a significantly decreased time negatively ( P Conclusions: represents highly significant marker carcinoma, which is able identify subset at high risk. this respect, it superior established such as nodal status, pT stage, p53 GASTROENTEROLOGY 2002;123:1478-1484
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M S Lakshmi, G V Sherbet, S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. Anticancer Research. ,vol. 18, pp. 2415- 2421 ,(1998)
P. S. Rudland, R. Barraclough, M. P. A. Davies, F. E. M. Gibbs, B. R. Davies, Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1 Oncogene. ,vol. 8, pp. 999- 1008 ,(1993)
Annie M. Young, D.J. Kerr, F.D. Richard Hobbs, ABC of colorectal cancer : BMJ Books. ,(2011)
H Endo, A Matsuura, K Wada, M Suzuki, O Matsuzaki, K Takenaga, H Nakanishi, Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas. Clinical Cancer Research. ,vol. 3, pp. 2309- 2316 ,(1997)
Angela Platt-Higgins, John H. R. Winstanley, Philip S. Rudland, Roger Barraclough, Christopher R. West, Christine Renshaw, Lynne Robertson, Prognostic Significance of the Metastasis-inducing Protein S100A4 (p9Ka) in Human Breast Cancer Cancer Research. ,vol. 60, pp. 1595- 1603 ,(2000)
Beat W. Schäfer, Claus W. Heizmann, The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends in Biochemical Sciences. ,vol. 21, pp. 134- 140 ,(1996) , 10.1016/S0968-0004(96)80167-8
Luca Mazzucchelli, Protein S100A4: Too Long Overlooked by Pathologists? American Journal of Pathology. ,vol. 160, pp. 7- 13 ,(2002) , 10.1016/S0002-9440(10)64342-8
C. PARKER, M.S. LAKSHMI, B. PIURA, G.V. SHERBET, Metastasis-Associated mts1 Gene Expression Correlates with Increased p53 Detection in the B16 Murine Melanoma DNA and Cell Biology. ,vol. 13, pp. 343- 351 ,(1994) , 10.1089/DNA.1994.13.343
Mohamed A. Elkablawy, Perry Maxwell, Kate Williamson, Neil Anderson, Peter W. Hamilton, Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival. The Journal of Pathology. ,vol. 194, pp. 436- 443 ,(2001) , 10.1002/PATH.894
R. von Wasielewski, M. Werner, M. Nolte, L. Wilkens, A. Georgii, Effects of antigen retrieval by microwave heating in formalin-fixed tissue sections on a broad panel of antibodies. Histochemistry and Cell Biology. ,vol. 102, pp. 165- 172 ,(1994) , 10.1007/BF00268892