Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

摘要: First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle changes not appreciated a of volume alone. In this study we adopt complementary methods assessing the integrity grey matter FEP patients and assess whether these relate patient clinical functional outcome at 3 year follow-up. 1.5 Tesla T1-weighted Magnetic Resonance (MR) images were acquired for 46 experiencing their first healthy controls. Cerebral cortical thickness local gyrification index (LGI) investigated using FreeSurfer software. Volume shape hippocampus, caudate lateral ventricles assessed manual tracing spherical harmonics applied description. A cluster thinning was compared controls; located right superior temporal gyrus, sulcus, extended into middle gyrus (lateral cortex - LTC). Bilateral volumes significantly lower relative controls also displayed regions deflation group. No significant abnormalities LGI or hippocampal ventricle volume/shape. Neither LTC nor related change symptom severity global functioning years later. are present but do appear directly affect outcome.