DEVIATIONS FROM HARDY-WEINBERG PROPORTIONS: SAMPLING VARIANCES AND USE IN ESTIMATION OF INBREEDING COEFFICIENTS

摘要: An analysis is made of the distribution deviations from Hardy-Weinberg proportions with k alleles and estimates inbreeding coefficients (f) obtained these deviations. If f small, best estimate in large samples shown to be 2 sigma i(Tii/Ni)/(k - 1), where Tii an unbiased measure excess ith homozygote Ni number allele sample [frequency = Ni/(2N)]. No extra information Tij, are departures numbers heterozygotes expectation. Alternatively, estimator can computed ignoring Tii. Also (1) variance equals 1/(N(k 1] when all individuals unrelated, test for 0 1 d.f. given by ratio its standard error; (2) reduced if some rare; (3) consists full-sib families size n, increased a proportion (n 1)/4 but not half-sib relationship. structure population critical importance. due inbred matings otherwise random-breeding population, as determined same genes expressions sampling variance. admixture, genes. The above probably close values.