DRY-POWDER OF CHITOSAN-COATED LIPID-CORE NANOCAPSULES CONTAINING DAPSONE: DEVELOPMENT, LASER DIFFRACTION CHARACTERIZATION AND ANALYTICAL QUANTIFICATION
作者： Rodrigo Cé , Denise Soledade Jornada , João Guilherme Barreto De Marchi , Silvia Stanisçuaski Guterres , Adriana Raffin Pohlmann
关键词:
摘要: Analytical techniques are critical for ensuring physical and chemical stability of a drug both assessing the molecules quantifying identifying content in products. We proposed development dry-powders lipid-core nanocapsules containing dapsone coated with chitosan, as well as, analytical quantification 1% 2% (m/v) leucine by high-performance liquid chromatography (HPLC). Size is most relevant physicochemical property nanoparticulated delivery systems. In this context, our results demonstrated that during powders redispersion water, could be observed mean particle diameters (DAP-LNC-CS-L1 DAP-LNC-CS-L2) decreased times increase. The spray-drying nanocapsule formulations showed yields ranging from 58 ± 1.0 % (DAP-LNC-CS-L1) to 61 1.5 (DAP-LNC-CS-L2) indicating an efficient drying process. quantifications dry HPLC ranged 92 1.4% 95 0.8% (DAP-LNC-CS-L1). Can concluded process DAP-LNC-CS-L1 DAP-LNC-CS-L2 aqueous dispersion spray-dryed were higher than 90%.
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