Micropartículas nanorrevestidas contendo um fármaco modelo hidrofóbico: preparação em etapa única e caracterização biofarmacêutica

摘要: The aim of this work was to prepare and characterize spray-dried nanocapsule-coated microparticles obtained in one step, using indomethacin as a hydrophobic drug model poly(e-caprolactone) or Eudragit® RS100, polymers. Nanocapsule-coated showed micrometric mean sizes (10 - 15 µm) reduced surface area (75 85 m2g-1) compared the raw material (214 m2g-1). Microparticles coated with RS100-nanocapsules better control release. release profiles fit monoexponetial Power Law. mechanism from is non-Fickian depends on particles desagglomeration.